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Other system-type approaches have been proposed to capture the complexity of biological aging (Zierer etal., 2015)Annu Rev Psycholdoi: 10.1136/bmj.g2219As evidence of their utility becomes available, further biomarkers could be added to, or substituted for items in, the current panel.From the available evidence it was not possible to rank the domains or sub-domains proposed nor to suggest how information from the various domains might be aggregated to provide a ‘healthy ageing’ score – even assuming that such a score is conceptually valid or of practical utilitydoi: 10.1016/S0140-6736(69)90950-7In both FHS generations, the incident risk for mortality, CVD, and diabetes of participants with signatures 2 through 26 was compared to the referent group (signature 1)2010;464:536542
[PMC free article] [PubMed] [Cross Ref]34Adoption of this approach may facilitate the comparability, and pooling, of data from a greater number of studies than is possible at present and so enhance research on healthy ageing[PMC free article] [PubMed] [Cross Ref]25Nat2007;370:18291839doi: 10.1097/PSY.0b013e31814c3e7cIf these analyses replicate in larger cohorts, biomarker signatures could be used for patient stratification in the design and analysis of clinical trials and go beyond studies to become tools for early preclinical diagnoses and more efficacious patient treatment in clinical settings.The selection of biomarkers to be measured in LLFS was based on known or putative roles of the biomarkers in aging and related diseases, and many of these biomarkers have been shown to change differentially in normally aging and healthy aging individuals (Newman etal., 2016)Biomarkers fulfilling all of the above AFAR criteria are unlikely to exist [6], and several candidate biomarkers of ageing have emerged in the past few decades but none has proved universally suitable for, or robust in, measuring or predicting the degree of ageing at either population or individual levels [13].Ageing affects all cells, organs and tissues and, in the majority of body systems, is characterised by the gradual loss of functioneventsHRP-valueSizeNo[PubMed] [Cross Ref]29
Additional signatures of biomarkers that may correlate to varying aging patterns, for example, disease-free aging, or aging with increased risk for diabetes or cardiovascular disease (CVD), will be characterized by a departure of subsets of the circulating biomarkers from the average distributiondoi: 10.1111/j.1749-6632.2000.tb06651.xdoi: 10.1016/S0140-6736(07)61778-4Aging and measures of processing speedRequest Permissions Keywordsbiological aging; biomarkers; healthy aging; morbidity and mortalityPublication HistoryIssue online: 3 March 2017Version of record online: 6 January 2017Manuscript Accepted: 15 November 2016Funded byNational Institute on AgingSciFig.S22 Reproduced biomarker signatures in FHS offspringMed
We identified nine domains together with tests commonly used for their assessment (Additional file 1: Table S3)doi: 10.1016/j.maturitas.2013.07.007Handbook on immunosenescence: basic understanding and clinical applicationsObjectively measured physical capability levels and mortality: systematic review and meta-analysisWe expect that many more biomarkers exist that could lead to even more powerful results, and as costs for measuring and processing proteomics data become more approachable and the technology more reliable, these analyses will be very informative2012;344:d7622Mech2010;45:242011;6:e27899
Lancet[PMC free article] [PubMed] [Cross Ref]54(DOCX 24 kb)2012;40:490498However, combinations of some of these biomarkers appear to predict biological age and the rate of ageing among young adults [54, 56], as well as frailty [57, 58], and further research in this area should help to identify whether the proposed biomarkers can be combined to produce an overall ‘ageing score’ and the circumstances in which such a score has practical utility.A further generic limitation of our work is uncertainty about the validity in very old people of putative biomarkers of healthy ageing which appear robust in younger-old individuals 3d39b66ab9
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Other system-type approaches have been proposed to capture the complexity of biological aging (Zierer etal., 2015)Annu Rev Psycholdoi: 10.1136/bmj.g2219As evidence of their utility becomes available, further biomarkers could be added to, or substituted for items in, the current panel.From the available evidence it was not possible to rank the domains or sub-domains proposed nor to suggest how information from the various domains might be aggregated to provide a ‘healthy ageing’ score – even assuming that such a score is conceptually valid or of practical utilitydoi: 10.1016/S0140-6736(69)90950-7In both FHS generations, the incident risk for mortality, CVD, and diabetes of participants with signatures 2 through 26 was compared to the referent group (signature 1)2010;464:536542
[PMC free article] [PubMed] [Cross Ref]34Adoption of this approach may facilitate the comparability, and pooling, of data from a greater number of studies than is possible at present and so enhance research on healthy ageing[PMC free article] [PubMed] [Cross Ref]25Nat2007;370:18291839doi: 10.1097/PSY.0b013e31814c3e7cIf these analyses replicate in larger cohorts, biomarker signatures could be used for patient stratification in the design and analysis of clinical trials and go beyond studies to become tools for early preclinical diagnoses and more efficacious patient treatment in clinical settings.The selection of biomarkers to be measured in LLFS was based on known or putative roles of the biomarkers in aging and related diseases, and many of these biomarkers have been shown to change differentially in normally aging and healthy aging individuals (Newman etal., 2016)Biomarkers fulfilling all of the above AFAR criteria are unlikely to exist [6], and several candidate biomarkers of ageing have emerged in the past few decades but none has proved universally suitable for, or robust in, measuring or predicting the degree of ageing at either population or individual levels [13].Ageing affects all cells, organs and tissues and, in the majority of body systems, is characterised by the gradual loss of functioneventsHRP-valueSizeNo[PubMed] [Cross Ref]29
Additional signatures of biomarkers that may correlate to varying aging patterns, for example, disease-free aging, or aging with increased risk for diabetes or cardiovascular disease (CVD), will be characterized by a departure of subsets of the circulating biomarkers from the average distributiondoi: 10.1111/j.1749-6632.2000.tb06651.xdoi: 10.1016/S0140-6736(07)61778-4Aging and measures of processing speedRequest Permissions Keywordsbiological aging; biomarkers; healthy aging; morbidity and mortalityPublication HistoryIssue online: 3 March 2017Version of record online: 6 January 2017Manuscript Accepted: 15 November 2016Funded byNational Institute on AgingSciFig.S22 Reproduced biomarker signatures in FHS offspringMed
We identified nine domains together with tests commonly used for their assessment (Additional file 1: Table S3)doi: 10.1016/j.maturitas.2013.07.007Handbook on immunosenescence: basic understanding and clinical applicationsObjectively measured physical capability levels and mortality: systematic review and meta-analysisWe expect that many more biomarkers exist that could lead to even more powerful results, and as costs for measuring and processing proteomics data become more approachable and the technology more reliable, these analyses will be very informative2012;344:d7622Mech2010;45:242011;6:e27899
Lancet[PMC free article] [PubMed] [Cross Ref]54(DOCX 24 kb)2012;40:490498However, combinations of some of these biomarkers appear to predict biological age and the rate of ageing among young adults [54, 56], as well as frailty [57, 58], and further research in this area should help to identify whether the proposed biomarkers can be combined to produce an overall ‘ageing score’ and the circumstances in which such a score has practical utility.A further generic limitation of our work is uncertainty about the validity in very old people of putative biomarkers of healthy ageing which appear robust in younger-old individuals 3d39b66ab9
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